2. Signaling Pathways
  3. Anti-infection
  4. Parasite

Parasite

Parasite

Related Products

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Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases such as nematodes, cestodes, trematodes, and infectious protozoa.

Parasite Isoform Specific Products:

Parasite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-118324
    10-Propoxydecanoic acid
    		Inhibitor
    10-Propoxydecanoic acid (compound 011) is a toxic myristate analog with an IC50 value of 14μM on KETRI 243.
    10-Propoxydecanoic acid
  • HY-149093
    Antileishmanial agent-14
    		Inhibitor
    Antileishmanial agent-14 is a sulfuretin analog with potential activity against the parasite Leishmania donovani promastigotes (IC50=4.1 μM). Antileishmanial agent-14 also inhibits infection by L. donovani amastigotes (IC50=11.1 μM).
    Antileishmanial agent-14
  • HY-107311
    Hederacholchiside E
    		Inhibitor
    Hederacholchiside E (compound 6) is a kind of saponin. Hederacholchiside E can be isolated from the Anemone raddeana.
    Hederacholchiside E
  • HY-121067
    Carbarsone
    		Inhibitor
    Carbarsone, also known as p-ureidobenzenearsonic acid, is historically used as an amebicide in human and veterinary medicine and extensively employed in poultry and swine feed, often in combination with antibiotics to prevent conditions like blackhead in turkeys. It exhibits relatively low acute toxicity, prompting investigations into its safety for food additives under the Federal Food, Drug, and Cosmetic Act. Studies aimed at assessing its potential carcinogenicity in laboratory animals have shown negative evidence similar to other arsanilic acid derivatives, suggesting minimal risk under chronic ingestion conditions. Metabolically, carbarsone is converted to arsanilic acid, which has been observed in preliminary studies involving dogs at high doses.
    Carbarsone
  • HY-B0529
    Azlocillin
    		Inhibitor
    Azlocillin, an antibiotic, is a semisynthetic penicillin, and has broad-spectrum antibacterial activity. Azlocillin is active against drug-tolerant B. burgdorferi sensu stricto JLB31 infection.
    Azlocillin
  • HY-136429
    Ethylhydrocupreine
    		Inhibitor 99.64%
    Ethylhydrocupreine (Optochin) is a quinine derivate with antimicrobial activity against S. pneumoniae. Ethylhydrocupreine also possesses antimalarial activity against Plasmodium falciparum, with an IC50 of 25.75 nM. Ethylhydrocupreine is a Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7) agonist.
    Ethylhydrocupreine
  • HY-135811
    Desethyl chloroquine
    		Inhibitor
    Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity.
    Desethyl chloroquine
  • HY-W751750
    Urethane-13C,15N
    Urethane-13C,15N (Ethyl carbamate-13C,15N) is the 13C- and 15N-labeled Urethane (HY-B1207). Urethane (Ethyl carbamate), the ethyl ester of carbamic acid, is a byproduct of fermentation found in various food products. Urethane has the ability to suppress bacterial, protozoal, sea urchin egg, and plant tissue growth in vitro.
    Urethane-<sup>13</sup>C,<sup>15</sup>N
  • HY-B0828R
    Triazophos (Standard)
    Triazophos (Standard) is the analytical standard of Triazophos. This product is intended for research and analytical applications. Triazophos, a non-systemic insecticide and acaricide that acts as an acetylcholinesterase (AChE) inhibitor, covalently and irreversibly binds to the acetylcholine binding site, thus blocking the hydrolysis of acetylcholine and leading to hyperexcitability; it is effective against a variety of soil insects and mites, including aphids, thrips, midges, beetles, Lepidoptera larvae, cutworms, and spider mites in crops such as ornamentals, cotton, rice, maize, soybeans, oil palms, olives, and coffee.
    Triazophos (Standard)
  • HY-175304
    DMU371
    		Inhibitor
    DMU371 is a Trypanosoma cruzi lysyl-tRNA synthetase 1 (KRS1) inhibitor (IC50=185 nM). DMU371 is promising for research of infectious diseases.
    DMU371
  • HY-168918
    Insecticidal agent 19
    		Inhibitor
    Insecticidal agent 19 (Compound 7b) exhibits antimalarial activity by inhibiting dihydrofolate reductase-thymidylate synthase (DHFR-TS) and pteridine reductase 1 (PTR1) through the folic acid metabolic pathway. Insecticidal agent 19 inhibits Leishmania major promastigote and amastigote with IC50 of 1.43 μM and 3.78 μM.
    Insecticidal agent 19
  • HY-D0143AR
    Quinine dihydrochloride (Standard)
    		Inhibitor
    Quinine (dihydrochloride) (Standard) is the analytical standard of Quinine (dihydrochloride). This product is intended for research and analytical applications. Quinine dihydrochloride is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine dihydrochloride is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM.
    Quinine dihydrochloride (Standard)
  • HY-108251R
    Methotrexate metabolite (Standard)
    Methotrexate metabolite (Standard) is the analytical standard of Methotrexate metabolite. This product is intended for research and analytical applications. Methotrexate metabolite (DAMPA), the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent.
    Methotrexate metabolite (Standard)
  • HY-13735H
    Quinacrine acetate
    		Inhibitor
    Quinacrine (Acriquine) acetate is a small molecule modulator of the cGAS-STING-TBK1 signaling pathway, possessing immune stimulatory activity. Quinacrine acetate has been explored for its potential therapeutic applications in enhancing anti-tumor immunity. Quinacrine acetate can improve the effectiveness of cancer immunotherapies by addressing the poor immunogenicity of various tumors. Quinacrine acetate also presents a promising strategy for overcoming the limitations associated with immune checkpoint inhibitors in cancer treatment.
    Quinacrine acetate
  • HY-B0177R
    Tinidazole (Standard)
    Tinidazole (Standard) is the analytical standard of Tinidazole. This product is intended for research and analytical applications. Tinidazole, an orally available antibacterial agent, is a 5-nitroimidazole with selective activity against anaerobic bacteria and protozoa.
    Tinidazole (Standard)
  • HY-126417
    Methylenetanshinquinone
    		Inhibitor
    Methylenetanshinquinone is a natural compound with antiplasmodial, antitrypanosomal and antioxidative activities. Methylenetanshinquinone can be used for the research of parasite infection.
    Methylenetanshinquinone
  • HY-146488
    Anti-infective agent 2
    		Inhibitor
    Anti-infective agent 2 (compound 3k) shows antiparasitic activity against P. falciparum and T. brucei rhodesiense, with IC50 values of 0.07 and 2.20 μM, respectively. Anti-infective agent 2 shows antimycobacterial activity against Mycobacterium smegmatis with a MIC of 32 μg/mL.
    Anti-infective agent 2
  • HY-149958
    Antileishmanial agent-17
    		Inhibitor
    Antileishmanial agent-17 is a coumarin hybrid compound with antileishmanial effects (IC50 <0.78 μM). Antileishmanial agent-17 is safe to normal VERO cells. Antileishmanial agent-17 binds to folate pathway enzymes pteridine reductase and DHFR-TS. And Antileishmanial agent-17 shows the most potent with IC50 value of 0.40 μM against promastigote and 0.68 μM against amastigote, respectivley.
    Antileishmanial agent-17
  • HY-125298
    Cycloaspeptide A
    		Inhibitor
    Cycloaspeptide A, isolated from the endophytic fungus Penicillium janczewskii, has antiparasitic activity.
    Cycloaspeptide A
  • HY-149810
    AcrB-IN-2
    		Inhibitor
    AcrB-IN-2 is an AcrB efflux pump inhibitor, with ability to potentiate the effect of antibiotics. AcrB-IN-22 inhibits Nile Red (a known substrate of AcrB) efflux.AcrB-IN-2 does not disrupts the bacterial outer membrane nor display toxicity in a nematode model.
    AcrB-IN-2
Parasite Isoform Comparison

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